Hydrochloric Acid → HCID 20559954, Verbindung

HRID 1974092Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1974092
[ClH:1].[NH2:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][CH2:6][C:7]1[CH:19]=[CH:18][C:10]([C:11]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=1>C(O)C>[ClH:1].[ClH:1].[NH2:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][CH2:6][C:7]1[CH:19]=[CH:18][C:10]([C:11]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 205599556-[2-(2-Aminophenyl)ethyl]-N,N-diethylpyridine-3-carboxamide

Produkt 1

HCID 20559954HCID 20559954, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

6-(o-Aminophenethyl)-N,N-diethylnicotinamide N,N-diethyl-6-(o-nitrostyryl)nicotinamide (16.3 g., 0.05 mole) reduced in 150 ml. of ethanol employing 0.1 g. of 10% palladium on carbon catalyst according to the procedure described in Example 2 (a) for 2-(o-aminophenethyl)pyridine provides 6-(o-aminophenethyl)-N,N-diethylnicotinamide base. Addition of ethanolic hydrogen chloride to the nicotinamide base in ethanol provides 6-(o-aminophenethyl)-N,N-diethylnicotinamide dihydrochloride, m.p. 224°-226° C. (corr.).

Quellen und Nachweise

ORD-Eintrag
ord-497ec71c261149c09a811d18a7f88b65
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US04000143

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