Reaktionsgleichung
[C:1](=O)([O-:4])[O:2]C.[Mg+2].COC(=O)[O-].[CH3:12][C:13]([C:15]1[O:16][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:18][CH:19]=1)=[O:14]>CN(C)C=O>[CH2:21]([O:20][C:17]1[O:16][C:15]([C:13]([CH2:12][C:1]([OH:4])=[O:2])=[O:14])=[CH:19][CH:18]=1)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 120 °C
Versuchsvorschrift
A mixture of magnesium methyl carbonate in dimethyl formamide (300 g of a 2.0 mM/g solution) is heated in a 120° C oil bath with stirring under carbon dioxide flushing for 1/2 hour. To this mixture is added 32.3 g (0.100 mole) of 5-(tetradecyloxy)-2-furyl methyl ketone, and the oil bath temperature is raised to 130° C to 150° C. Dry nitrogen is flushed through the mixture for 5 hours. The mixture is allowed to cool to room temperature under carbon dioxide flushing after which it is poured slowly into 2 liters of concentrated HCl-ice (1:1) with vigorous stirring. When the evolution of gas is complete the precipitate is collected and washed with cold water, then dried to give 2-[5-(tetradecyloxy)-2-furoyl]acetic acid.
Aufarbeitung
- temperaturethe oil bath temperature is raised to 130° C to 150° C
- customDry nitrogen is flushed through the mixture for 5 hours
- temperatureto cool to room temperature under carbon dioxide flushing after which it
- additionis poured slowly into 2 liters of concentrated HCl-ice (1:1) with vigorous stirring
- customis collected
- washwashed with cold water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-f259936cb63541eca807b5877fdc3ddf
- Quelldatensatz
- uspto-grants-1976_12
- Patentnummer
- US04000164
Verknüpfte Notizen
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