Phosphorus oxychloride → 2,5-Dichloropyridin-3-Ol

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[C:5](O)=[N:6][CH:7]=1.P(Cl)(Cl)([Cl:12])=O>>[Cl:12][C:5]1[C:4]([OH:9])=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 178516188HCID 178516188, Verbindung

Produkt 1

HCID 98989172,5-Dichloropyridin-3-Ol

Reaktionsbedingungen

Temperatur: 180 °C

Versuchsvorschrift

A mixture of 5-chloro-2,3-dihydroxypyridine (1.0g.) and phosphoryl chloride (10ml.) was heated overnight at 180° C. in a sealed tube. The phosphoryl chloride was distilled off, and the residue was chromatographed, to give 2,5-dichloro-3-hydroxypyridine, m.p. 160°-161° C. (ethyl acetate - petrol).

Aufarbeitung

distillationThe phosphoryl chloride was distilled off
customthe residue was chromatographed

Quellen und Nachweise

ORD-Eintrag: ord-71e68871133342e1acdfbb3c36b31865
Quelldatensatz: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04000305

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