Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride
Reaktionsgleichung
[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]Komponenten
3
Versuchsvorschrift
4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.
Aufarbeitung
- concentrationThe product is concentrated
- customthe crystals are triturated with acetone
- filtrationfiltered off with suction
- dry with materialdried in a vacuum desiccator over P4O10
Quellen und Nachweise
- ORD-Eintrag
- ord-09706ab2dac248c9b2ece0af30bd9028
- Quelldatensatz
- uspto-grants-1994_02
- Patentnummer
- US05284842
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