Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1975004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1975004
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 19100972Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

Produkt 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The batch is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

Aufarbeitung

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-97a973d345d248c7bc927724b14b2d0f
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284855

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