HCID 19100959, Verbindung → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1975013Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1975013
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

Komponenten

3

Edukt 1

HCID 19100959HCID 19100959, Verbindung

Produkt 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0 ]octane-7-carboxylate together with 30 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 30 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 mi portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-3b7d2e3ebd244f23b5466b3961aa741e
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284855

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