HCID 19100973, Verbindung → HCID 19100943, Verbindung

HRID 1975028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1975028
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

Komponenten

3

Edukt 1

HCID 19100973HCID 19100973, Verbindung

Produkt 1

HCID 19100943HCID 19100943, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 100 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 20 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-15f90691a1d34175a558224d4324b463
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284855

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