Acetyl chloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Reaktionsgleichung
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:12]1[CH:34]=[CH:33][C:15]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[CH2:20][CH2:19]2)=[O:17])=[CH:14][CH:13]=1)C(=O)C)([CH3:4])[CH3:3].C(Cl)(=O)C>>[CH:2]([O:5][CH2:6][CH2:7][NH:8][C:12]1[CH:34]=[CH:33][C:15]([C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[CH2:22][CH2:23]2)=[O:17])=[CH:14][CH:13]=1)([CH3:4])[CH3:3]Komponenten
3
Versuchsvorschrift
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-acetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 142°-144° is obtained from 3 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine by reaction with acetyl chloride.
Quellen und Nachweise
- ORD-Eintrag
- ord-9b52d251c89e43fc9ee9104673bebd5a