HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2-(4-Fluorophenyl)ethyl)piperazine → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| Edukt | 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride | HCID 19099416 | — |
| Produkt | 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine | HCID 19099419 | — |
Reaktionsschritte
Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 0.9 g of [2-(4-fluorophenyl)ethyl]piperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine. The hydrochloride thereof melts at 166°-167°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05286728 |
| Quelldatensatz | uspto-grants-1994_02 |
| ORD ID | ord-ee022453f72f46ca9740381ffa49db10 |
| Quellennotiz | uspto-grants-1994_02 |