Dimethylamine → 3-bromo-N,N-dimethyl-5-(trifluoromethyl)pyridin-2-amine
Reaktionsgleichung
Cl[C:2]1[C:7]([Br:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[CH3:13][NH:14][CH3:15]>>[Br:8][C:7]1[C:2]([N:14]([CH3:15])[CH3:13])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1Komponenten
3
Versuchsvorschrift
2-Chloro-3-bromo-5-trifluoromethylpyridine (509 mg, 1.95 mmol) was treated with ethanolic dimethylamine solution (10 ml) and heated at reflux for 2 hrs before being concentrated. The residue was partitioned between water (10 ml) and ethyl acetate (10 ml), and the organic phase washed with brine (10 ml) and dried (Na2SO4). The solution was then concentrated to give the product as a yellow oil (430 mg, 82% yield).
Aufarbeitung
- temperatureheated
- temperatureat reflux for 2 hrs
- concentrationbefore being concentrated
- customThe residue was partitioned between water (10 ml) and ethyl acetate (10 ml)
- washthe organic phase washed with brine (10 ml)
- dry with materialdried (Na2SO4)
- concentrationThe solution was then concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-e0b49f56cb46443fb2047f51ce983857
- Quelldatensatz
- uspto-grants-2001_05
- Patentnummer
- US06225320B1
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