6-Bromohexanamide → 4-[7-(1-Adamantyl)-6-carbamoylpentyloxy-2-naphthyl]benzoic acid

HRID 1976164

Reaktionsgleichung

Reaktionsgleichung von HRID 1976164
[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:21]5[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=5)=[CH:18]4)=[CH:13][C:12]=3[OH:31])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.Br[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([NH2:40])=[O:39]>>[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:21]5[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=5)=[CH:18]4)=[CH:13][C:12]=3[O:31][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[NH2:40])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

Komponenten

3

Edukt 2

HCID 3219746-BromohexanamideHCID 22000367Methyl 4-[7-(1-adamantyl)-6-hydroxy-2-naphthyl]benzoate

Produkt 1

HCID 702309324-[7-(1-Adamantyl)-6-carbamoylpentyloxy-2-naphthyl]benzoic acidAusbeute 65,6 %

Versuchsvorschrift

Following the procedure of Example 12(a), but reacting 640 mg (1.55 mmol) of methyl 4-[7-(1-adamantyl)-6-hydroxy-2-naphthyl]benzoate with 450 mg (2.32 mmol) of 6-bromohexanamide, 520 mg (65%) of the expected compound were obtained, which compound had a melting point of 209°-10° C.

Quellen und Nachweise

ORD-Eintrag
ord-530f64406b1d4ee588c744046266f245
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06225328B1

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