Hydrochloric Acid → 4-[7-(1-Adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzenemethanol

HRID 1976168

Reaktionsgleichung

Reaktionsgleichung von HRID 1976168
[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:21]5[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=5)=[CH:18]4)=[CH:13][C:12]=3[O:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.B.Cl>C1COCC1>[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:21]5[CH:29]=[CH:28][C:24]([CH2:25][OH:26])=[CH:23][CH:22]=5)=[CH:18]4)=[CH:13][C:12]=3[O:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6331BoraneHCID 216241CD 2665

Produkt 1

HCID 702291984-[7-(1-Adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzenemethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

3 g (6.1 mmol) of 4-[7-(1-adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzoic acid and 40 ml of THF were introduced into a three-necked flask under a stream of nitrogen. 20 ml of a solution of borane (1M in THF) were added dropwise and the reaction mixture was heated at 40° C. for one hour. The reaction mixture was poured into a 1N hydrochloric acid solution and extracted with ethyl acetate and the organic phase was separated by settling, dried over magnesium sulfate and evaporated.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customthe organic phase was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-001ebf85415340179869c6543ca861cd
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06225328B1

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