Isatoic Anhydride → (11aR)-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5,11-Dione

HRID 1976227Notizen

Reaktionsgleichung

[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=[O:12])[O:4][C:2]2=O.[NH:13]1[CH2:20][CH2:19][CH2:18][C@@H:14]1C(O)=O>>[CH2:19]1[C@@H:20]2[C:5](=[O:12])[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=3[C:2](=[O:4])[N:13]2[CH2:14][CH2:18]1

Komponenten

Edukt 2

HCID 8359Isatoic Anhydride

HCID 8988D-Proline

Produkt 1

HCID 677115(11aR)-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5,11-DioneAusbeute 78,9 %

Versuchsvorschrift

The same procedures used in the method B in Reference Example 19 were repeated except for the use of isatoic anhydride and D-proline to form the title compound. Yield 78.9%.

Quellen und Nachweise

ORD-Eintrag: ord-bc3439b5ae454d738203c6c8c0964cfb
Quelldatensatz: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06225306B1

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