2-Bromo-6-methylbenzoic acid → 4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-bromo-6-methylphenyl)carbonyl]-L-phenylalanine methyl ester

HRID 1976995

Reaktionsgleichung

Reaktionsgleichung von HRID 1976995
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:9][CH:8]=1)[NH2:5].[Br:25][C:26]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[C:27]=1[C:28](O)=[O:29]>>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:11][CH:12]=1)[NH:5][C:28]([C:27]1[C:31]([CH3:35])=[CH:32][CH:33]=[CH:34][C:26]=1[Br:25])=[O:29]

Komponenten

3

Edukt 2

HCID 27355892-Bromo-6-methylbenzoic acidHCID 233839334-(2,6-Dichlorobenzoylamino)-L-phenylalanine methyl ester

Produkt 1

HCID 537588504-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-bromo-6-methylphenyl)carbonyl]-L-phenylalanine methyl esterAusbeute 64 %

Versuchsvorschrift

4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-bromo-6-methylphenyl)carbonyl]-L-phenylalanine methyl ester was prepared in 64% yield from 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester and 2-bromo-6-methylbenzoic acid using the general procedure described in example 3. HR MS: Obs. mass, 563.0138. Calcd. mass, 563.0140 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-de1e3a1fcaa5424f9d6366fdd122164d
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06229011B1

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