4-Bromoanisole → HCID 21996968, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][C:12](C)=[CH:11][CH:10]=1)=[O:8].Br[C:20]1C=CC(OC)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]([CH3:20])[CH:14]=1)=[O:8]Komponenten
3
Versuchsvorschrift
Employing the same general procedure as for the preparation 5-bromo-2-methoxy-4′-methylbenzophenone (Compound H), 1.0 mL (1.5 g, 8.0 mmol) of 4-bromoanisole was converted into the title compound using 0.5 g (4.0 mmol) of aluminum chloride, 1.3 mL (1.5 g, 9.6 mmol) of m-toluoyl chloride and 20 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-e379606b67b849c98e0ae781d65554c3
- Quelldatensatz
- uspto-grants-2001_05