Hydrochloric Acid → N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

HRID 1978461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978461
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:30]>C(O)C>[ClH:30].[ClH:30].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21994006N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Produkt 1

HCID 21994005N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a solution of 479 mg (1.18 mmol) of N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4 mM) of 4N-HCl/methnol and the mixture was stirred at room temperature for several minutes. The solvent was then distilled off under reduced pressure and the residue was diluted with ethanol and diethyl ether. The resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound.

Aufarbeitung

  1. distillationThe solvent was then distilled off under reduced pressure
  2. additionthe residue was diluted with ethanol and diethyl ether
  3. filtrationThe resulting crystals were collected by filtration
  4. washrinsed with ethanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-b19b43e1783142e29dc42b5848319df9
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235731B1

Notizen zur Reaktion

Wird geladen…