Hydrochloride methanol → n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978468Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978468
[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1.[ClH:34].CO>C(O)C>[ClH:34].[ClH:34].[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21994003N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Produkt 1

HCID 21994085n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 244 mg (0.52 mM) of N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4.0 mM) of 4N-HCl/methanol. The solvent was distilled off under reduced pressure and the residue was purified by recrystallization to provide the title compound.

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-e19fa9d90bc04d3aac069dfd736a4bc1
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235731B1

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