Hydrochloric Acid → n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978528Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978528
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:15][CH2:14]1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:17][CH2:18]1)#[N:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21993749N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Produkt 1

HCID 21993748n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochlorideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To an ethanol solution (8.0 ml) of N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid (3.0 ml). The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol to give the object compound (462 mg, 70%), m.p.234-240° C.

Aufarbeitung

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7418d139f4d54df091a3197e88cd0233
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235731B1

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