Hydrochloric Acid → N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978530
[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21994000N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Produkt 1

HCID 21993999N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To an ethanol solution (8.0 ml) of N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid. The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol (4622 mg, 70%), m.p.169-172° C.

Aufarbeitung

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol (4622 mg, 70%), m.p.169-172° C.

Quellen und Nachweise

ORD-Eintrag
ord-b7c75ca6a961497d8efd75e88ec569c2
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235731B1

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