Propylamine → HCID 135537129, Verbindung

HRID 1978867Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978867
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

Komponenten

4

Edukt 2

HCID 7852PropylamineHCID 178458304HCID 178458304, Verbindung

Produkt 1

HCID 135537129HCID 135537129, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)-pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on washing with water. The residue was recrystallized from isopropanol:water to yield the title compound, 0.56 g, m.p. 172-3° C.

Aufarbeitung

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-621a7352cd934cf3a2398eeb0b01d0d7
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06239136B1

Notizen zur Reaktion

Wird geladen…