Sodium Hydroxide → HCID 1793644, Verbindung

HRID 1979721Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1979721
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[CH:15][C:16](Cl)=[N:17][C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2.[OH-:21].[Na+]>C(O)CCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[CH:15][C:16]([O:21][CH2:4][CH2:3][CH2:12][CH3:11])=[N:17][C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 46787202-Chloro-6,7-dihydro-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one

Produkt 1

HCID 1793644HCID 1793644, VerbindungAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

1.46 g of 9,10-dimethoxy-6,7-dihydro-2-chloro-4H-pyrimido(6,1-a)isoquinolin-4-one are added to a mixture of 1.0 g of sodium hydroxide and 50.0 ml of n-butanol. The reduction mixture is refluxed for 6 hours. The solvent is removed under reduced pressure. The residue is treated with water and extracted with chloroform. The extract is dried over anhydrous Na2SO4 and evaporated to give a white solid. After crystallization from a chloroform-ether mixture, 0.7 g of the title compound is obtained, m.p. 158°-159° C.

Aufarbeitung

  1. temperatureThe reduction mixture is refluxed for 6 hours
  2. customThe solvent is removed under reduced pressure
  3. additionThe residue is treated with water
  4. extractionextracted with chloroform
  5. dry with materialThe extract is dried over anhydrous Na2SO4
  6. customevaporated
  7. customto give a white solid
  8. customAfter crystallization from a chloroform-ether mixture

Quellen und Nachweise

ORD-Eintrag
ord-52ec23814c77492cb17822f72233488a
Quelldatensatz
uspto-grants-1984_11
Patentnummer
US04482556

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