O-Allylhydroxylamine → 2-[1-(Allyloxyimino)propyl]-5-(4-methanesulfonamidophenyl)-3-hydroxy-2-cyclohexen-1-one

HRID 1979836

Reaktionsgleichung

Reaktionsgleichung von HRID 1979836
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][C:16](=[O:18])[C:15]([C:19](=O)[CH2:20][CH3:21])=[C:14]([OH:23])[CH2:13]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[CH2:24]([O:27][NH2:28])[CH:25]=[CH2:26]>O1CCCC1>[CH2:24]([O:27][N:28]=[C:19]([C:15]1[C:16](=[O:18])[CH2:17][CH:12]([C:9]2[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:11][CH:10]=2)[CH2:13][C:14]=1[OH:23])[CH2:20][CH3:21])[CH:25]=[CH2:26]

Komponenten

4

Edukt 2

HCID 420841O-AllylhydroxylamineHCID 178458872HCID 178458872, Verbindung

Produkt 1

HCID 1361999692-[1-(Allyloxyimino)propyl]-5-(4-methanesulfonamidophenyl)-3-hydroxy-2-cyclohexen-1-oneAusbeute 68,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Into 10 ml of tetrahydrofuran was dissolved 1.0 g of 5-(4-methanesulfonamidophenyl)-3-hydroxy-2-propionyl-2-cyclohexen-1-one and to the solution was added 0.5 g of allyloxyamine. The mixture was kept at room temperature for 15 hours and then it was treated with similar process in Example 1. Thus, 0.8 g of the objective compound was obtained. It was colorless crystals having a melting point of 134°-135° C.

Aufarbeitung

  1. additionit was treated with similar process in Example 1

Quellen und Nachweise

ORD-Eintrag
ord-7c91ec55f3d14d1481e47f800440632f
Quelldatensatz
uspto-grants-1984_11
Patentnummer
US04482740

Verknüpfte Notizen

Wird geladen…