[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH3:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22].C(OC(C)C)(C)C>C(N(CC)CC)C.C(#N)C>[CH3:13][O:12][C:10]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[Cl:14])(=[O:22])=[O:23])=[O:26])[N:11]=11.5 g (0.0069 mol) of 2-amino-4-methoxypteridine and two drops of triethylamine were added to a mixture of 1.77 g (0.01 mol) of 2-chlorophenylsulfonyl isocyanate in 20 ml of acetonitrile and the mixture was refluxed for 30 minutes, cooled and mixed with diisopropyl ether. After standing for 10 minutes, the mixture was vacuum filtered to obtain 2.25 g (87% of theory) of N-(4-methoxypteridin-2-yl)-N'-(2-chlorophenylsulfonyl)-urea melting at 212° C.
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