Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)- → methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate

HRID 1980447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1980447
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([N+]([O-])=O)[CH:6]=1.[CH2:25]([P:27]([O:30]C)[O:28][CH3:29])[CH3:26]>C(#N)C>[CH2:25]([P:27]([C:7]1[CH:6]=[C:5]([O:4][C:3]2[CH:17]=[CH:18][C:19]([C:21]([F:24])([F:23])[F:22])=[CH:20][C:2]=2[Cl:1])[CH:10]=[CH:9][C:8]=1[N+:11]([O-:13])=[O:12])(=[O:30])[O:28][CH3:29])[CH3:26]

Komponenten

4

Edukt 2

HCID 156238Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-HCID 2784207Dimethyl ethylphosphonite

Produkt 1

HCID 13456449methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (1.6 g, 4.4 mmol), dimethyl ethylphosphonite (1 ml, 8.8 mmol) and acetonitrile (6 ml) is stirred at room temperature overnight. The reaction mixture is concentrated to dryness, and the residue is purified by preparative thin layer chromatography (silica gel, eluting with 10% ethyl acetate/hexane) to give methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated to dryness
  2. customthe residue is purified by preparative thin layer chromatography (silica gel, eluting with 10% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-1e0abddf00e54693a35b1fcc5cf6e3bc
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04509970

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