Triethylamine → N-[2-(2-chloroethoxy)-phenylsulfonyl]-N'-methylurea

HRID 1981252

Reaktionsgleichung

Reaktionsgleichung von HRID 1981252
C(N(CC)CC)C.[Cl:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[S:18]([NH2:21])(=[O:20])=[O:19].[CH3:22][N:23]=[C:24]=[O:25]>C(Cl)Cl>[Cl:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[S:18]([NH:21][C:24]([NH:23][CH3:22])=[O:25])(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 137294542-(2-Chloroethoxy)benzene-1-sulfonamide

Produkt 1

HCID 20191437N-[2-(2-chloroethoxy)-phenylsulfonyl]-N'-methylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5.9 g of triethylamine is added dropwise to a suspension of 11.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, 50 ml of methylene chloride and 3.3 g of methyl isocyanate within 10 minutes at a temperature of 20°-25° C. The resulting clear solution is stirred for a further hour at room temperature and evaporated to dryness. The residue is solved in 5% aqueous sodium carbonate. After acidification of this solution with 10% hydrochloric acid 12.5 g of N-[2-(2-chloroethoxy)-phenylsulfonyl]-N'-methylurea precipitate therefrom, m.p. 218°-222° C.

Aufarbeitung

  1. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0e073cf3a0c54dcbb0f73461526f3edb
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04514212

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