2-Amino-4,6-dimethoxypyrimidine → HCID 13374376, Verbindung

HRID 1981262

Reaktionsgleichung

Reaktionsgleichung von HRID 1981262
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[N:12]([S:15]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]1[O:26][CH:27]=[N:28][N:29]=1)(=[O:17])=[O:16])=[C:13]=[O:14]>O1CCCC1>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:13]([NH:12][S:15](=[O:17])(=[O:16])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]2[O:26][CH:27]=[N:28][N:29]=2)=[O:14])[N:7]=1

Komponenten

4

Edukt 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 133743752-(1,3,4-Oxadiazol-2-yl)phenyl isocyanatosulfonate

Produkt 1

HCID 13374376HCID 13374376, VerbindungAusbeute 11,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a suspension of 6 g of 2-amino-4,6-dimethoxypyrimidine in 25 ml of tetrahydrofuran was added a solution of 8 g of the isocyanate prepared in Example 3 dissolved in 25 ml of tetrahydrofuran. After an initial exotherm, the solution was stirred at 25° C. for 16 hours, to yield a precipitate. The mixture was filtered, and the solid was recrystallized from acetonitrile to yield 1.5 g of the title compound; m.p. 161°-164° C.

Aufarbeitung

  1. customto yield a precipitate
  2. filtrationThe mixture was filtered
  3. customthe solid was recrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-52fe3c3b6548476390e9c170fc8881bd
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04514214

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