Fuming sulfuric acid → Sulfuric Acid

HRID 1981596

Reaktionsgleichung

Reaktionsgleichung von HRID 1981596
ClC1C=C(C=CC=1)NCCC(O)=O.ClC1C=C2C(C(=O)CCN2)=CC=1.[OH:26][S:27]([OH:30])(=[O:29])=[O:28].O=S(=O)=O.F.[B:36]([F:39])([F:38])[F:37]>>[S:27](=[O:28])(=[O:26])([OH:30])[OH:29].[FH:37].[B:36]([F:39])([F:38])[F:37]

Komponenten

7

Edukt 4

HCID 24681Fuming sulfuric acidHCID 889747-Chloro-2,3-dihydro-4-quinoloneHCID 9855450Trifluoroborane HydrofluorideHCID 124709193-((3-Chlorophenyl)amino)propanoic acid

Produkt 3

HCID 1118Sulfuric AcidHCID 6356Boron trifluorideHCID 14917Hydrofluoric Acid

Versuchsvorschrift

It should, however, be noted that, in the particular case of the cyclisation of 3-(m-chloroanilino)-propionic acid by polyphosphoric acid, a mixture of substantially equal quantities of 5-chloro- and 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is obtained. The selectivity for 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is significantly improved if an oleum or a hydrofluoric acid/boron trifluoride mixture is used as cyclisation agent, but the industrial use of these processes encounters difficulties which result either from the handling of large quantities of sulphuric acid or from the utilisation of a mixture of anhydrous hydrofluoric acid and boron trifluoride.

Aufarbeitung

  1. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-5e819d090e934416b6a5282c4fb537b0
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04593101

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