HCID 54119678, Verbindung → 2'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine

HRID 1981884Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1981884
C([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11]C(=O)C2C=CC=CC=2)[O:8][C@@H:7]([N:20]2[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]2=[O:22])[C@H:6]1[F:29])(=O)C>N>[F:29][C@H:6]1[C@H:5]([OH:4])[C@@H:9]([CH2:10][OH:11])[O:8][C@H:7]1[N:20]1[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]1=[O:22]

Komponenten

3

Edukt 1

HCID 54119678HCID 54119678, Verbindung

Produkt 1

HCID 1723922'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosineAusbeute 81,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 222AmmoniaLösungsmittel

Versuchsvorschrift

1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine (1.0 g) is dissolved in saturated methanolic ammonia (100 ml) and the solution is left standing for 24 hours at room temperature. The solvent is removed in vacuo and the residue was crystallized from ethanol to give 560 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine, m.p. 201°-202°.

Aufarbeitung

  1. waitthe solution is left
  2. customThe solvent is removed in vacuo
  3. customthe residue was crystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f16d908274074347954bd7d6e9b1f9ae
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04594339

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