Methyl 2-iodopropanoate → 6-t-Butoxycarbonylamino-4-N-(1-carbomethoxyethyl)-perhydro-1,4-thiazepin-5-one

HRID 1981893

Reaktionsgleichung

Reaktionsgleichung von HRID 1981893
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:15][S:14][CH2:13][CH2:12][NH:11][C:10]1=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].I[CH:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]>>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:15][S:14][CH2:13][CH2:12][N:11]([CH:18]([C:19]([O:21][CH3:22])=[O:20])[CH3:23])[C:10]1=[O:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 143426Methyl 2-iodopropanoateHCID 15591256(Hexahydro-5-oxo-1,4-thiazepin-6-yl)carbamic acid, (1,1-dimethylethyl) ester

Produkt 1

HCID 233180436-t-Butoxycarbonylamino-4-N-(1-carbomethoxyethyl)-perhydro-1,4-thiazepin-5-oneAusbeute 81,5 %

Versuchsvorschrift

The above-named compound is prepared from 6-t-butoxycarbonylamino-perhydro-1,4-thiazepin-5-one (0.1 g) and methyl iodopropionate (0.11 g) according to the procedure described in Example 4. The product (0.11 g) is obtained after chromatography. The NMR spectrum is consistent with the assigned structure.

Quellen und Nachweise

ORD-Eintrag
ord-46d0b1599906477e95e6886d9c3ce496
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04594341

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