Formaldehyde → [3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

HRID 1982993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1982993
[CH:1]([C:4]1[CH:8]=[CH:7][NH:6][N:5]=1)([CH3:3])[CH3:2].[CH2:9]=[O:10].C(N(CC)CC)C>CC(C)=O>[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][OH:10])[N:5]=1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 178439403HCID 178439403, Verbindung

Produkt 1

HCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanolAusbeute 87,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

The mixture of 1.15 g of 3-i-propyl-1H-pyrazole, 0.94 g of paraformaldehyde and 0.14 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filterate was concentrated under reduced pressure
  4. additionHexane was added to the residue
  5. customcrystalline was formed
  6. customThe crystalline was collected

Quellen und Nachweise

ORD-Eintrag
ord-eeae46a0051743e3a770b198ff9cba6f
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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