Formaldehyde → [3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol

Temperatur

80 °C

The mixture of 4.08 g of 3-(trifluoromethyl)-1H-pyrazole, 2.00 g of paraformaldehyde and 1 ml of triethylamine was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 4.31 g of 3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. filtrationThe mixture was filtered
3. concentrationThe filterate was concentrated under reduced pressure
4. additionHexane was added to the residue
5. customcrystalline was formed
6. customThe crystalline was collected

ORD-Eintrag

ord-1dc556a7a7964805b58ede2195bf92a1

Quelldatensatz

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07541374B2