Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983000
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 23149202[3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol

Produkt 1

HCID 196193331-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.33 g of 3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.44 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-945e5508e1e64fcd81ee8f6e1d218a32
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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