Formaldehyde → 1-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

HRID 1983003Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983003
[C:1]([C:3]1[CH:7]=[CH:6][NH:5][N:4]=1)#[N:2].[CH2:8]=[O:9]>CC(C)=O>[OH:9][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:1]#[N:2])=[N:4]1

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 178510229HCID 178510229, Verbindung

Produkt 1

HCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrileAusbeute 78,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

The mixture of 0.86 g of 3-cyano-1H-pyrazole and 0.55 g of paraformaldehyde was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. After the mixture was filtered, the filterate was concentrated under reduced pressure to obtain 0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationAfter the mixture was filtered
  3. concentrationthe filterate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b89ab9f59ab34374bd4b9245c26fa816
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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