Thionyl Chloride → 1-(chloromethyl)-3-cyano-1H-pyrazole

HRID 1983004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983004
O[CH2:2][N:3]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[N:4]1.S(Cl)([Cl:12])=O>ClCCl>[C:8]([C:5]1[CH:6]=[CH:7][N:3]([CH2:2][Cl:12])[N:4]=1)#[N:9]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

Produkt 1

HCID 231491551-(chloromethyl)-3-cyano-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole was dissolved to 30 ml of dichloromethane. 1.6 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.00 g of 3-cyano-1-(chloromethyl)-1H-pyrazole.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4048f98994ec4a3f9dab9965e6aea239
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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