Thionyl Chloride → 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

HRID 1983006Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983006
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([CH2:12]O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[Cl:16][CH2:12][N:9]1[CH:10]=[CH:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 23149203(3-phenyl-1H-pyrazol-1-yl)methanol

Produkt 1

HCID 231491981-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.74 g of 3-phenyl-1H-pyrazole-1-ylmethanol was dissolved to 50 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. Hexane and chloroform was added to the residue to produce a crystal. The crystal was collected to obtain 2.01 g of 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionHexane and chloroform was added to the residue
  3. customto produce a crystal
  4. customThe crystal was collected

Quellen und Nachweise

ORD-Eintrag
ord-9e26bc2e22b947a69d9be7f84f70836b
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

Notizen zur Reaktion

Wird geladen…