Thionyl Chloride → 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983012Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983012
[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[ClH:15].[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 231491454-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol

Produkt 1

HCID 231491914-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3.79g of 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol was dissolved to 45 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The solid obtained was washed with hexane and chloroform to obtain 3.69 g of 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe solid obtained
  3. washwas washed with hexane and chloroform

Quellen und Nachweise

ORD-Eintrag
ord-56fd97145ef649b2b0011fc8590641ef
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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