Thionyl Chloride → 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983018
[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 231491424-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

Produkt 1

HCID 231491474-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.9 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The obtained solid was washed with the mixture of hexane and chloroform to obtain 3.33 g of 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe obtained solid was washed with the mixture of hexane and chloroform

Quellen und Nachweise

ORD-Eintrag
ord-744ce6921e4a47f9907faf0034c55224
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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