Thionyl Chloride → 1-(chloromethyl)-3,5-dimethyl-1H-pyrazole hydrochloride
Reaktionsgleichung
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8]O)[N:3]=1.S(Cl)([Cl:12])=O>ClCCl>[ClH:12].[Cl:12][CH2:8][N:4]1[C:5]([CH3:7])=[CH:6][C:2]([CH3:1])=[N:3]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
0.63 g of 3,5-dimethyl-1H-pyrazole-1-ylmethanol was dissolved to 25 ml of dichloromethane. 1.2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 0.93 g of 1-(chloromethyl)-3,5-dimethyl-1H-pyrazole hydrochloride.
Aufarbeitung
- concentrationThe reaction mixture was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-571f806eb95f40789a06bdbe4b8b9f32
- Quelldatensatz
- uspto-grants-2009_06
- Patentnummer
- US07541374B2
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