Thionyl Chloride → 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983021Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983021
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:11])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][Cl:11])[CH:6]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 7017837(4-chloro-1H-pyrazol-1-yl)methanol

Produkt 1

HCID 231491194-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2.73 g of 4-chloro-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 4.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.90 g of 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4ba79de6830f453fbdf6b7841f6f2834
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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