Formaldehyde → 4-(Trifluoromethyl)-1H-pyrazole-1-methanol

HRID 1983023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983023
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][N:6]([CH2:10][OH:11])[CH:7]=1

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 127777954-(Trifluoromethyl)-1H-pyrazole

Produkt 1

HCID 231491674-(Trifluoromethyl)-1H-pyrazole-1-methanolAusbeute 83,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

The mixture of 0.59 g of 4-(trifluoromethyl)-1H-pyrazole and 0.26 g of paraformaldehyde was stirred at 130° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The residue was concentration under reduced pressure to obtain 0.60 g of 4-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationconcentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f77e9e4b74ab44bf8ad91cda84084c59
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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