Formaldehyde → 1-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983037
[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][NH:5][N:4]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][N:5]([CH2:10][OH:11])[N:4]=1

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 178506277HCID 178506277, Verbindung

Produkt 1

HCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazoleAusbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

The mixture of 2.74 g of 3-(trifluoromethyl)-1H-1,2,4-triazole and 1.20 g of paraformaldehyde was stirred at 150° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture, and the mixture was filtered. The filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 3.15 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe mixture was filtered
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-62a792cdb76445bc966e229dbf830580
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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