Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983038Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983038
[F:1][C:2]([F:11])([F:10])[C:3]1[N:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[N:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

Produkt 1

HCID 231491371-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.52 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol was dissolved to 50 ml of dichloromethane, and 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.36 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole.

Aufarbeitung

  1. additionwas added to the solution
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-78c4601423424f22baf8de452c249ad8
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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