Thionyl Chloride → 1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole
Reaktionsgleichung
[F:1][C:2]([F:14])([C:7]1[CH:11]=[CH:10][N:9]([CH2:12]O)[N:8]=1)[C:3]([F:6])([F:5])[F:4].S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:12][N:9]1[CH:10]=[CH:11][C:7]([C:2]([F:14])([F:1])[C:3]([F:6])([F:5])[F:4])=[N:8]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1.98 g of 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 1.5 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.01 g of 1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole.
Aufarbeitung
- concentrationThe reaction mixture was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-99c8ffda75f04edc8a1dbea01c0c1090
- Quelldatensatz
- uspto-grants-2009_06
- Patentnummer
- US07541374B2
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