Formaldehyde → 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

HRID 1983045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983045
[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:11])([F:10])[F:9])=[N:4][NH:5][CH:6]=1.[CH2:14]=[O:15]>CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:9])([F:10])[F:11])=[N:4][N:5]([CH2:14][OH:15])[CH:6]=1

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 178506331HCID 178506331, Verbindung

Produkt 1

HCID 231491334-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanolAusbeute 50,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

The mixture of 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole and 3.00 g of paraformaldehyde was stirred at 130° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure. Hexane was added to the filtrate, as a result, a crystal was formed. The crystal was collected to obtain 7.69 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. additionHexane was added to the filtrate, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

Quellen und Nachweise

ORD-Eintrag
ord-c67c9c6a8c9245d48876786e720d34a7
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541374B2

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