5-Methyl-3-phenyl-4-isoxazolecarbohydrazide → HCID 16722754, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[F:17][CH:18]([F:29])[O:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](O)=O>>[F:17][CH:18]([F:29])[O:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22]1[O:14][C:13]([C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[N:15][N:16]=1Komponenten
3
Versuchsvorschrift
As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using 2-(difluoromethoxy)-benzoic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=70:10:20 to 40:40:20, 294 mg, 86%) which was obtained as a white solid. MS: m/e=370.0 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-0d18d5a870f34acdaa7919a0cb215a14
- Quelldatensatz
- uspto-grants-2009_06