HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → 1-(4-Fluorophenoxy)-2-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | 4-Fluorophenol | HCID 9732 | — |
| Edukt | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Edukt | 2-(4-Fluorophenoxy)aniline | HCID 6485399 | — |
| Produkt | 1-(4-Fluorophenoxy)-2-nitrobenzene | HCID 961127 | 75% |
| Produkt | N-[2-(4-Fluorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732937 | 72% |
Reaktionsschritte
2-(4-Fluorophenoxy)-1-nitrobenzene (0.87 g, 75%) was prepared from 4-fluoro-phenol (0.62 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-fluorophenoxy)aniline (0.51 g, 68%) following general procedure B. N-[2-(4-Fluorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (118 mg, 72%) was prepared from 2-(4-fluorophenoxy)aniline (102 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07541373B2 |
| Quelldatensatz | uspto-grants-2009_06 |
| ORD ID | ord-203f80ffd9ff4fd795236569ea5e8d6a |
| Quellennotiz | uspto-grants-2009_06 |