Dimethylamine → HCID 57713885, Verbindung

HRID 1984047Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984047
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[NH:14][CH3:15])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].C(OCC)(=O)C.[CH3:22][NH:23][CH3:24]>>[CH3:22][N:23]([CH3:24])[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[NH:14][CH3:15])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3]

Komponenten

4

Edukt 3

HCID 674DimethylamineHCID 8857Ethyl AcetateHCID 57713890HCID 57713890, Verbindung

Produkt 1

HCID 57713885HCID 57713885, VerbindungAusbeute 92 %

Versuchsvorschrift

3-(Chlorosulfonyl)-4-(methylamino)benzoic acid (1.2, 0.515 g, 2.06 mmol) was dissolved in ethyl acetate (8 mL, 0.08 mol). Dimethylamine (0.4 mL, 0.008 mol) was added next. The reaction was left to stir for 4 hours. The reaction was extracted with 0.5 M HCl, washed with water and brine, and the organic layer dried over magnesium sulfate. The ethyl acetate was evaporated and the crude product 1.3.Af was obtained in 92% yield. MS analysis (m−1)=257.

Aufarbeitung

  1. waitThe reaction was left
  2. extractionThe reaction was extracted with 0.5 M HCl
  3. washwashed with water and brine
  4. dry with materialthe organic layer dried over magnesium sulfate
  5. customThe ethyl acetate was evaporated
  6. customwas obtained in 92% yield

Quellen und Nachweise

ORD-Eintrag
ord-594541c22e49437db4f254a9f996dd28
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544676B2

Notizen zur Reaktion

Wird geladen…