Methylamine → N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide

HRID 1984092Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984092
[CH2:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)[CH2:8][CH2:7]1)[CH2:2][CH2:3][C:4]#[CH:5].[CH3:24][NH2:25]>C1COCC1>[CH3:24][NH:25][C:12]([N:9]1[CH2:8][CH2:7][N:6]([CH2:1][CH2:2][CH2:3][C:4]#[CH:5])[CH2:11][CH2:10]1)=[O:14]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 866082224-Nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate

Produkt 1

HCID 86608223N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 4-nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate (1.37 g) in THF (10 mL) was treated with 40% aq. MeNH2 (10 mL) at 70 C for 2 h. The mixture was concentrated and diluted with conc. NH4OH (5 mL) and water (15 mL). Extraction (DCM, 80 mL) and concentration gave N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide (0.659 g).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. additiondiluted with conc. NH4OH (5 mL) and water (15 mL)
  3. extractionExtraction (DCM, 80 mL) and concentration

Quellen und Nachweise

ORD-Eintrag
ord-6e8e602585e94f56a77d716f682e1eae
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544672B2

Notizen zur Reaktion

Wird geladen…