4-(2,4-Dimethylphenyl)piperazin-1-ylethylamine → 1-t-Butyl-5-(4-chlorophenyl)-3-{2-[4-(2,4-dimethylphenyl)piperazin-1-yl]-ethyl}aminomethylpyrazole

HRID 1984153Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984153
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[N:29]([C:30]([CH3:33])([CH3:32])[CH3:31])[N:28]=[C:27]([CH:34]=O)[CH:26]=2)=[CH:21][CH:20]=1>>[C:30]([N:29]1[C:25]([C:22]2[CH:21]=[CH:20][C:19]([Cl:18])=[CH:24][CH:23]=2)=[CH:26][C:27]([CH2:34][NH:17][CH2:16][CH2:15][N:12]2[CH2:13][CH2:14][N:9]([C:3]3[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=3[CH3:1])[CH2:10][CH2:11]2)=[N:28]1)([CH3:33])([CH3:32])[CH3:31]

Komponenten

3

Edukt 2

HCID 47424664-(2,4-Dimethylphenyl)piperazin-1-ylethylamineHCID 866110605-(4-Chlorophenyl)-1-t-butylpyrazole-3-carbaldehyde

Produkt 1

HCID 160385641-t-Butyl-5-(4-chlorophenyl)-3-{2-[4-(2,4-dimethylphenyl)piperazin-1-yl]-ethyl}aminomethylpyrazoleAusbeute 60,3 %

Versuchsvorschrift

Compound 33 was prepared using the same method as that of Example 1 except that 4-(2,4-dimethylphenyl)piperazin-1-ylethylamine and 5-(4-chlorophenyl)-1-t-butyl pyrazole-3-carbaldehyde were used.

Quellen und Nachweise

ORD-Eintrag
ord-6b8e05c62e9b4767b62e13b79e870617
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544686B2

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