Phosphorus oxychloride → 1,5-diethyl-1H-pyrazole-3-carbonitrile

Reaktionsgleichung

[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]([NH2:12])=O)=[N:4]1)[CH3:2].P(Cl)(Cl)(Cl)=O>>[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]#[N:12])=[N:4]1)[CH3:2]

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 669585351,5-diethyl-1H-pyrazole-3-carboxamide

Produkt 1

HCID 669583001,5-diethyl-1H-pyrazole-3-carbonitrileAusbeute 101,9 %

Versuchsvorschrift

1,5-Diethyl-1H-pyrazole-3-carboxamide (8.3 g, 0.050 mol) was treated with phosphorous oxychloride (35 mL) according to the method described in Part C of Example 7. The reaction was heated for 2.5 hours to provide 7.6 g of 1,5-diethyl-1H-pyrazole-3-carbonitrile as a yellow oil, which was used without purification.

Aufarbeitung

temperatureThe reaction was heated for 2.5 hours

Quellen und Nachweise

ORD-Eintrag: ord-8fbe5a250fc640b3b7166c5e5d358e2a
Quelldatensatz: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07544697B2

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